Increasingly sensitive techniques are available for the detection and quantification of MRD in multiple myeloma. Each technique offers advantages and inherent limitations that might differentially affect their use and interpretation of the findings.44
ASO: allele-specific oligonucleotide; CT: computed tomography; MFC: multiparameter flow cytometry; NGS: next-generation sequencing; PCR: polymerase chain reaction; PET: position emission tomography.
A publication from the U.S. Food & Drug Administration (FDA) discussing regulatory perspectives on MRD testing in multiple myeloma concluded that MRD assessment in multiple myeloma has the potential to become a surrogate clinical endpoint that could be used to support regulatory purposes for drug review. Standardization of MRD testing and consensus within the multiple myeloma community as to the role of MRD will be integral steps toward this end.45
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