Minimal residual disease (MRD) refers to the small number of malignant cells below the limit of detection available with conventional morphologic assessment.53 In multiple myeloma, MRD refers to myeloma cells that are present in the bone marrow after a clinical response has been measured and the patient is in remission. These residual myeloma cells are clinically relevant, as they may lead to disease progression and relapse.17,54
The response criteria have evolved over time due to therapeutic advances in multiple myeloma. In 1998, a conventional complete response (CR) required bone marrow aspirates with less than 5% plasma cells, irrespective of their clonal nature. Current technology allows for further identification of myeloma cells by cell-surface markers expression and genomic architecture.54
ASO-PCR, allele-specific oligonucleotide polymerase chain reaction; BM, bone marrow; FC, flow cytometry; IF, immunofluorescence; IHC, immunohistochemistry; MM, multiple myeloma; NGF, next-generation flow; NGS, next-generation sequencing; PC, plasma cells
Multiple myeloma is an evolving disease state, and Amgen plans several substantive updates to the content of this site in the coming months. Please subscribe to be notified as these updates become available. Your email will not be used for any other purpose and you can unsubscribe at any time.
Please send me a notification when myelomarevealed.com content is updated.