While outcomes have improved with the recent availability of targeted agents and
combination therapies, most patients with multiple myeloma (MM) inevitably
relapse.11,12 With each subsequent line of therapy, the duration and quality of
response deteriorates, and the risk of another relapse increases.11,13,14
At the time of diagnosis, the cellular and genetic architecture of multiple myeloma is highly complex and heterogeneous across patients.9,15 Many patients harbor anywhere from three to seven detectable subclones.16 Within each patient clonal diversity continuously evolves throughout the treatment continuum.9 Somatic mutations, chromosomal translocations and deletions, and epigenetic modifications accumulate over time within myeloma clones as the disease advances. This evolution may occur through branching pathways, where mutations create different clones that may drive disease evolution and treatment resistance.7 Genetic heterogeneity of these myeloma cells highlight the need for simultaneously targeting multiple mechanisms of disease, including protein degradation.17,18
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