Home > Quality of Life Assessments
Health-related quality of life
Patient-reported outcomes (PROs) measure aspects of a patient's health status that come
directly from the patient, including health-related quality of life (HRQoL). HRQoL
instruments provide a means of assessing treatment benefit and can be important tools in
clinical research and practice.77 HRQoL is
becoming an increasingly important assessment tool in multiple myeloma, given the
improved survival outcomes from recent treatment advances. There are multiple
well-validated instruments available which can be used in clinical trials to facilitate
comparisons between treatments.75,77
Select HRQoL instruments
| Instrument75,78,79 |
Use |
Domains/Categories |
Measurement |
| EORTC-QLQ-C30 |
Cancer Patients |
Global health status/QoL
Functional domains: physical, role, emotional, cognitive and social
Symptom domains: fatigue, nausea, pain |
4-point Likert scale (not at all, a little, quite a
bit, very much)80
|
| EORTC-QLQ-MY20*(MY24) |
MM-specific tool used with QLQ-C30 |
Disease symptoms, side effects of treatment, body image
and future perspectives |
4-point Likert scale (not at all, a little, quite a
bit, very much)80,81 |
| EORTC-QLQ-CIPN20 |
Chemotherapy-induced peripheral neuropathy |
Sensory, motor and autonomic subscales |
4-point Likert scale (not at all, a little, quite a
bit, very much)82
|
| FACT-MM |
MM-specific tool |
Physical, social, emotional and functional well-being
and additional concerns |
5-point Likert scale (not at all, a little bit,
somewhat, quite a bit, very much)83 |
| EuroQoL-5D |
General HRQoL questionnaire |
Mobility, self care, usual activities, pain/discomfort,
anxiety/depression |
3L: Levels 1-3 (no problem, some problems, extreme
problems) 5L: Levels 1-5 (no problem, slight problems, moderate
problems, severe problems, extreme problems)84 |
| |
| Instrument75,78,79
|
EORTC-QLQ-C30 |
| Use |
Cancer patients |
| Domains/Categories |
Global health status/QoL Functional domains: physical, role, emotional,
cognitive and social
Symptom domains: fatigue, nausea, pain |
| Measurement |
4-point Likert scale (not at all, a little, quite a bit, very
much)80 |
| |
| Instrument75,78,79
|
EORTC-QLQ-MY20* (MY24) |
| Use |
MM-specific tool used with QLQ-C30 |
| Domains/Categories |
Disease symptoms, side effects of treatment, body image and future
perspectives |
| Measurement |
4-point Likert scale (not at all, a little, quite a bit, very
much)80,81 |
| |
| Instrument75,78,79
|
EORTC-QLQ-CIPN20 |
| Use |
Chemotherapy-induced peripheral neuropathy |
| Domains/Categories |
Sensory, motor and autonomic subscales |
| Measurement |
4-point Likert scale (not at all, a little, quite a bit, very
much)82 |
| |
| Instrument75,78,79
|
FACT-MM |
| Use |
MM-specific tool |
| Domains/Categories |
Physical, social, emotional and functional well-being and additional
concerns |
| Measurement |
5-point Likert scale (not at all, a little, somewhat, quite a bit, very
much)83 |
| |
| Instrument75,78,79
|
EuroQoL-5D |
| Use |
General HRQoL questionnaire |
| Domains/Categories |
Mobility, self care, usual activities, pain/discomfort, anxiety/depression
|
| Measurement |
3L: Levels 1-3 (no problem, some problems, extreme problems) 5L: Levels 1-5
(no problem, slight problems, moderate problems, severe problems, extreme
problems)84 |
*Validated for MM and widely used.